Getting My ceesdekker.net To Work

Employing single-molecule optical and AFM imaging and force-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions consist of:

Human Rad51 filaments on double- and one-stranded DNA: correlating typical and irregular sorts with recombination perform.

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Deposition and atomic force microscopy of individual phthalocyanine polymers between nanofabricated electrodes

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Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes

Considering that 2000 he moved to solitary-molecule biophysics and nanobiology, with research from DNA supercoiling experiments of nucleosomes and DNA repair service proteins to DNA translocation by way of nanopores. Not too long ago his study has focused on finding out cell division with microbes on chip, when his final interest is from the route of realizing artificial cells.

Atomic power microscopy demonstrates that vaccinia topoisomerase IB generates filaments on DNA in a cooperative style

What if, in lieu of employing conventional top rated-down silicon electronics, transistors might be crafted from the bottom up working with single organic and natural molecules since the switching features? This idea, which turned the basis of nowadays’s field of ceesdekker molecular electronics, 1st emerged in the seventies.

one). The existing–voltage curves showed significant modulations with gate voltage, even at area temperature, which was consistent with band bending in the ~0.six eV bandgap semiconducting nanotube. These information also confirmed which the conductance may be modulated by 6 orders of magnitude by altering the gate voltage. The final results of this operate — a home-temperature transistor produced from one carbon nanotube molecule — were revealed in Mother nature in May 1998.

Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with research from reports of DNA loop extrusion and supercoiling to DNA translocation via nanopores. Extra just lately his research has centered on studying chromatin framework and mobile division with germs on chip, though he is additionally seeking to in the end Establish synthetic cells from The underside up.

Later on we spoke all over again briefly simply because Dekker felt that our discussion of his faith speedily turned purely philosophical, Whilst In addition it concretely assists him in his perform.

Visualization of unstained DNA nanostructures with State-of-the-art in-aim transmission electron microscopy techniques

Solid-point out nanopores have tested to be a surprisingly versatile probe for one-molecule Assessment of DNA. I'll describe a few of our new results – exclusively DNA knots – and also our attempts to broaden the abilities of stable-condition nanopores even additional, in the course of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.